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Tabelle 1

Glaxo
Sumatriptan
(Imigran®)
Zeneca
Zolmitriptan
(Zomig®)
Glaxo
Naratriptan
(Naramig®)
MSD
Rizatriptan (10mg)
(Maxalt®)
HWZ (h) 2 2,5 – 3,5 6 2 – 3
Tmax (h) 1,5 2 – 4 2 – 3 1 – 1,5
Bioverfügbarkeit (oral) 14% 40% 63 – 74% 40 – 45%
Response (2h) ~60% ~60% 45% ~70%
KS-Freiheit ~30% 35-45% 26-28% ~40%
Begleitsymptome ++ ++ ++ ++
Recurrence <40% ~30% 24% > 40%

DMKG
UPass